Chemical analysis of a marine-derived fungus, Chaunopycnis sp. (CMB-MF028), isolated from the inner tissue of a pulmonate false limpet Siphonaria sp., collected from rock surfaces in the intertidal zone of Moora Park, Shorncliffe, Queensland, yielded the tetramic acid F-14329 (1) and new analogues, chaunolidines A-C (2-4), together with the new pyridinone chaunolidone A (5), and pyridoxatin (6). Structures inclusive of absolute configurations were assigned to 1-6 on the basis of detailed spectroscopic analysis, X-ray crystallography, electronic circular dichroism (ECD), biosynthetic considerations and chemical inter-conversion. Chaunolidine C (4) exhibits modest Gram-positive antibacterial activity (IC50 5-10 mu M), while chaunolidone A (5)...
A study of the secondary metabolism of two northeastern Pacific sponges and two Sri Lankan nudibranc...
Research Doctorate - Doctor of Philosophy (PhD)A colourimetric GTPase assay was utilised to screen a...
Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated fro...
Eight new tetramic acid derivatives, cladosporiumins A-H (1-8) were isolated from a culture broth of...
Small molecules from natural sources are vital to drug discovery by providing molecular diversity an...
For more than thirty years, marine natural products chemists have studied sponges, ascidians, and ot...
Drug discovery is reliant on new developments in natural product chemistry as well as advances in ch...
As part of an international research project, the marine fungal strain collection of the Helmholtz C...
thesisMarine organisms produce a wide variety of metabolites that display diverse biological activit...
Marine invertebrates are known to produce many structurally diverse secondary metabolites with uniqu...
Thesis (Ph. D.)--University of Hawaii at Manoa, 1994.Includes bibliographical references (leaves 97-...
dissertationMarine organisms have been shown to produce a wide variety of biologically active second...
Previously unreported anthraquinone, acetylpenipurdin A (4), biphenyl ether, neospinosic acid (6), d...
In our effort to discover promising anticancer agents, we have screened a series of compounds for th...
As part of an international research project, the marine fungal strain collection of the Helmholtz C...
A study of the secondary metabolism of two northeastern Pacific sponges and two Sri Lankan nudibranc...
Research Doctorate - Doctor of Philosophy (PhD)A colourimetric GTPase assay was utilised to screen a...
Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated fro...
Eight new tetramic acid derivatives, cladosporiumins A-H (1-8) were isolated from a culture broth of...
Small molecules from natural sources are vital to drug discovery by providing molecular diversity an...
For more than thirty years, marine natural products chemists have studied sponges, ascidians, and ot...
Drug discovery is reliant on new developments in natural product chemistry as well as advances in ch...
As part of an international research project, the marine fungal strain collection of the Helmholtz C...
thesisMarine organisms produce a wide variety of metabolites that display diverse biological activit...
Marine invertebrates are known to produce many structurally diverse secondary metabolites with uniqu...
Thesis (Ph. D.)--University of Hawaii at Manoa, 1994.Includes bibliographical references (leaves 97-...
dissertationMarine organisms have been shown to produce a wide variety of biologically active second...
Previously unreported anthraquinone, acetylpenipurdin A (4), biphenyl ether, neospinosic acid (6), d...
In our effort to discover promising anticancer agents, we have screened a series of compounds for th...
As part of an international research project, the marine fungal strain collection of the Helmholtz C...
A study of the secondary metabolism of two northeastern Pacific sponges and two Sri Lankan nudibranc...
Research Doctorate - Doctor of Philosophy (PhD)A colourimetric GTPase assay was utilised to screen a...
Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated fro...