Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: Results from an ex vivo study
- Shekar, Kiran
- Roberts, Jason A
- Mcdonald, Charles I
- Ghassabian, Sussan
- Anstey, Chris
- Wallis, Steven C
- Mullany, Daniel V
- Fung, Yoke L
- Fraser, John F
Publication date
April 2015
DOI Publisher
Springer Science and Business Media LLCAbstract
Introduction: Vital drugs may be degraded or sequestered in extracorporeal membrane oxygenation (ECMO) circuits, with lipophilic drugs considered to be particularly vulnerable. However, the circuit effects on protein-bound drugs have not been fully elucidated. The aim of this experimental study was to investigate the influence of plasma protein binding on drug disposition in ex vivo ECMO circuits
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