Placental fibroblast growth factor 21 is not altered in late-onset preeclampsia
- Dekker Nitert, Marloes
- Scholz-Romero, Katherin
- Kubala, Marta H.
- McIntyre, H. David
- Callaway, Leonie K.
- Barrett, Helen L.
Publication date
March 2015
DOI Publisher
Springer Science and Business Media LLCAbstract
Background: Preeclampsia (PE) is associated with alterations of placental function. The incidence of PE is higher in insulin resistant states. Women with PE have high circulating levels of the metabolic regulator fibroblast growth factor 21 (FGF21). FGF21 is synthesized in the placenta. The aim of this study was to compare the expression of FGF21, its receptors, downstream targets and transcriptional regulators in placental tissue from pregnancies with and without late-onset PE. Circulating FGF21 in maternal and cord blood was also studied
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