IL-6 driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anti-citrullinated peptide antibody-negative rheumatoid arthritis.
- Anderson, Amy E.
- Pratt, Arthur G.
- Sedhom, Mamdouh A. K.
- Doran, John Paul
- Routledge, Christine
- Hargreaves, Ben
- Brown, Philip M.
- Cao, Kim-Anh Le
- Isaacs, John D.
- Thomas, Ranjeny
Publication date
February 2015
DOI Publisher
BMJ ISSN
0003-4967 Citation count (estimate)
24Abstract
Objectives A previously identified signal transduction and activator of transcription-3 (STAT3) target-enriched gene signature in circulating CD4+ T cells of patients with early rheumatoid arthritis (RA) was prominent in autoantibody-negative individuals. Here, interleukin (IL)-6-mediated STAT signalling was investigated in circulating lymphocytes of an independent early arthritis patient cohort, seeking further insight into RA pathogenesis and biomarkers of potential clinical utility
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