High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice
- Baillet, Athan C.
- Rehaume, Linda
- Benham, Helen
- O'Meara, Connor P.
- Armitage, Charles W.
- Ruscher, Roland
- Brizard, Geraldine
- Harvie, Marina C. G.
- Velasco, Jared
- Hansbro, Phillip
- Forrester, John V.
- Degli-Esposti, Mariapia
- Beagley, Kenneth W.
- Thomas, Ranjeny
DOIAbstract
Objective. Chlamydia trachomatis is a sexually transmitted obligate intracellular pathogen that causes inflammatory reactive arthritis, spondylitis, psoriasiform dermatitis, and conjunctivitis in some individuals after genital infection. The immunologic basis for this inflammatory response in susceptible hosts is poorly understood. As ZAP-70(W163C)-mutant BALB/c (SKG) mice are susceptible to spondylo-arthritis after systemic exposure to microbial -glucan, we undertook the present study to compare responses to infection with Chlamydia muridarum in SKG mice and BALB/c mice
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