Cardiac Resynchronization Therapy: History, Present Status, and Future Directions

Background: Cardiac resynchronization therapy (CRT) is one of the most exciting recent advancements in heart failure (HF) treatment. Methods: This review surveys the available literature regarding the effectiveness of CRT in treating patients with HF. Results: By targeting ventricular dyssynchrony, CRT attempts to give the failing heart a mechanical advantage that can substantially improve both symptoms and mortality. Conclusion: CRT results in short-term and long-term improvement in cardiac structure and function, often leading to enhanced quality of life and, for some patients, enhanced survival