Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man
- Coughlan, Melinda T.
- Patel, Sheila K.
- Jerums, George
- Penfold, Sally A.
- Nguyen, Tuong-Vi
- Sourris, Karly C.
- Panagiotopoulos, Sianna
- Srivastava, Piyush M.
- Cooper, Mark E.
- Burrell, Louise M.
- MacIsaac, Richard J.
- Forbes, Josephine M.
Publication date
October 2011
DOI Publisher
S. Karger AG ISSN
1421-9670 Citation count (estimate)
20Abstract
Background/Aims: The formation of advanced glycation end products (AGEs) is accelerated in patients with diabetic nephropathy. The aim of this study was to ascertain if the urinary excretion of proteins modified by advanced glycation can be used as biomarkers for albuminuria in individuals with type 1 or type 2 diabetes. Methods: Community-based patients with type 1 (n = 68) or type 2 diabetes (n = 216) attending a diabetes clinic of a tertiary referral hospital were classified as having normoalbuminuria (Normo, albumin excretion rate (AER
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