Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression
- Culverhouse, Robert C.
- Bowes, Lucy
- Breslau, Naomi
- Nurnberger, John I. Jr
- Burmeister, Margit
- Fergusson, David M.
- Munafo, Marcus
- Saccone, Nancy L.
- Bierut, Laura J.
- 5-HTTLPR, Stress, and Depression Consortium
- Wray, Naomi
- Middeldorp, Christel
Publication date
November 2013
DOI Publisher
Springer Science and Business Media LLCAbstract
Background: Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting the risk for depression, others report a main effect of 5-HTTLPR variation on depression, while others find no evidence for either a main or interaction effect. Meta-analyses of multiple studies have also reached differing conclusions
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