Tension-sensitive actin assembly supports contractility at the epitherlial zonula adherens
- Leerberg, Joanne M.
- Gomez, Guillermo A.
- Verma, Suzie
- Moussa, Elliott J.
- Wu, Selwin K.
- Priya, Rashmi
- Hoffman, Brenton D.
- Grashoff, Carsten
- Schwartz, Martin A.
- Yap, Alpha S.
DOIAbstract
Background: Actomyosin-based contractility acts on cadherin junctions to support tissue integrity and morphogenesis. The actomyosin apparatus of the epithelial zonula adherens (ZA) is built by coordinating junctional actin assembly with Myosin II activation. However, the physical interaction between Myosin and actin filaments that is necessary for contractility can induce actin filament turnover, potentially compromising the contractile apparatus itself
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