Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: Potential role in pulmonary fibrosis
- Borensztajn, K. (Keren)
- Bresser, P. (Paul)
- Loos, C.M. (Chris) van der
- Bot, I. (Ilze)
- Blink, B. (Bernt) van den
- Bakker, M.A. (Michael) den
- Daalhuisen, J. (Joost)
- Groot, A.P. (Angelique)
- Peppelenbosch, M.P. (Maikel)
- Thusen, J.H. (Jan) von der
- Spek, C.A. (Arnold)
DOIAbstract
Idiopathic pulmonary fibrosis constitutes the most devastating form of fibrotic lung disorders and remains refractory to current therapies. The coagulation cascade is frequently activated during pulmonary fibrosis, but this observation has so far resisted a mechanistic explanation. Recent data suggest that protease-activated receptor (PAR)-2, a receptor activated by (among others) coagulation factor (F)Xa, plays a key role in fibrotic disease; consequently, we assessed the role of PAR-2 in the development of pulmonary fibrosis in this study
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