WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
- Zheng, H.-F. (Hou-Feng)
- Tobias, J.H. (Jon)
- Duncan, E.L. (Emma)
- Evans, D.M. (David)
- Eriksson, J. (Joel)
- Paternoster, L. (Lavinia)
- Yerges-Armstrong, L.M. (Laura)
- Lehtimäki, T. (Terho)
- Bergström, U. (Ulrica)
- Kähönen, M. (Mika)
- Leo, P.J. (Paul)
- Raitakari, O. (Olli)
- Laaksonen, M. (Marika)
- Nicholson, G.C. (Geoffrey)
- Viikari, J. (Jorma)
- Ladouceur, M. (Martin)
- Lyytikäinen, L.-P. (Leo-Pekka)
- Medina-Gomez, M.C. (Carolina)
- Rivadeneira Ramirez, F. (Fernando)
- Prince, R.L. (Richard)
- Sievanen, H. (Harri)
- Leslie, W.D. (William)
- Mellström, D. (Dan)
- Eisman, J.A. (John)
- Movérare-Skrtic, S. (Sofia)
- Goltzman, D. (David)
- Hanley, G.E. (Gillian)
- Jones, G. (Graeme)
- St Pourcain, B. (Beate)
- Xiao, Y. (Yanling)
- Timpson, N.J. (Nicholas)
- Smith, A.V. (Davey)
- Reid, I.R. (Ian)
- Ring, S.M. (Susan)
- Sambrook, P.N. (Philip)
- Karlsson, M. (Magnus)
- Dennison, E.M. (Elaine)
- Kemp, J.P. (John)
- Danoy, P. (Patrick)
- Sayers, I. (Ian)
- Wilson, S.G. (Scott)
- Nethander, M. (Maria)
- McCloskey, E.V. (Eugene)
- Vandenput, L. (Liesbeth)
- Eastell, R. (Richard)
- Idzenga, T. (Tim)
- Spector, T.D. (Timothy)
- Mitchell, B.D. (Braxton)
- Streeten, E.A. (Elizabeth)
- Brommage, R. (Robert)
- Pettersson-Kymmer, U. (Ulrika)
- Brown, M.A. (Matthew)
- Ohlsson, C. (Claes)
- Richards, J.B. (Brent)
- Lorentzon, M. (Mattias)
DOIAbstract
We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture i
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