GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice
- García, M.E. (Marcos)
- Klein Wolterink, R.G.J. (Roel)
- Lemâitre, F. (Fabrice)
- Le Goff, C. (Carine)
- Hasan, M. (Milena)
- Hendriks, R.W. (Rudi)
- Cumano, A. (Ana)
- Santo, J.P. (James) di
Publication date
March 2013
DOI Publisher
American Society of Hematology ISSN
0006-4971 Citation count (estimate)
44Abstract
Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint involves Notch1 signaling that instructs T-cell commitment at the expense of the B-lineage program. While GATA-3 is required for T-cell specification, its mechanism of action is poorly understood. We show that GAT
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