Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells
- Hartsink-Segers, S.A. (S.)
- Exalto, C. (Carla)
- Allen, M. (Matthew)
- Williamson, D. (Daniel)
- Clifford, S.C. (Steven)
- Horstmann, M.A. (Martin)
- Caron, H.N. (Huib)
- Pieters, R. (Rob)
- Boer, M.L. (Monique) den
DOIAbstract
This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia. Polo-like kinase 1 protein and Thr210 phosphorylation levels were higher in pediatric acute lymphoblastic leukemia (n=172) than in normal bone marrow mononuclear cells (n=10) (P<0.0001). High Polo-like kinase 1 protein phosphorylation, but not expression, was associated with a lower probability of event-free survival (P=0.042) and was a borderline significant prognostic factor (P=0.065) in a multivariate analysis including age and initial white blood cell count. Polo-like kinase 1 was necessary for leukemic cell surviva...
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