To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- and dynamic properties of interphase chromosomes and cell nuclei were simulated with Monte Carlo and Brownian Dynamics methods. The 30 nm chromatin fibre was folded according to the Multi-Loop-Subcompartment (MLS) model, in which ~100 kbp loops form rosettes, connected by a linker, and the Random-Walk/Giant-Loop (RW/GL) topology, in which 1-5 Mbp loops are attached to a flexible backbone. Both the MLS and the RW/GL model form chromosome territories but only the MLS rosettes result in distinct subcompartments visible with light microscopy and low overlap of chromosomes, -arms and subcompartments. This morphology and the size of subcompa...
Genomes are one of the major foundations of life due to their role in information storage, process r...
Genomes are one of the major foundations of life due to their role in information storage, process r...
Genomes are one of the major foundations of life due to their role in information storage, process r...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
Despite the successful linear sequencing of the human genome its three-dimensional structure is wide...
Despite the successful linear sequencing of the human genome its three-dimensional structure is wide...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
textabstractTo approach the three-dimensional organization of the human cell nucleus, the structural...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
textabstractTo approach the three-dimensional organization of the human cell nucleus, the structural...
textabstractTo approach the three-dimensional organization of the human cell nucleus, the structural...
Genomes are one of the major foundations of life due to their role in information storage, process r...
Genomes are one of the major foundations of life due to their role in information storage, process r...
Genomes are one of the major foundations of life due to their role in information storage, process r...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
Despite the successful linear sequencing of the human genome its three-dimensional structure is wide...
Despite the successful linear sequencing of the human genome its three-dimensional structure is wide...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
textabstractTo approach the three-dimensional organization of the human cell nucleus, the structural...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
To approach the three-dimensional organization of the human cell nucleus, the structural-, scaling- ...
textabstractTo approach the three-dimensional organization of the human cell nucleus, the structural...
textabstractTo approach the three-dimensional organization of the human cell nucleus, the structural...
Genomes are one of the major foundations of life due to their role in information storage, process r...
Genomes are one of the major foundations of life due to their role in information storage, process r...
Genomes are one of the major foundations of life due to their role in information storage, process r...