Translocation detection in lymphoma diagnosis by split-signal FISH: A standardised approach

Lymphomas originating from the lymphatic system comprise about 30 entities classified according to the World Health Organization (WHO). The histopathological diagnosis is generally considered difficult and prone to mistakes. Since non-random chromosomal translocations are specifically involved in different lymphoma entities, their detection will be increasingly important. Hence, a splitsignal fluorescence in situ hybridisation (FISH) procedure would be helpful in discriminating the most difficult classifications. Th