HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein
- Brandenburg, A.H. (Afke)
- Waal, L. (Leon) de
- Timmerman, H.H. (Helga)
- Hoogerhout, P. (Peter)
- Swart, R.L. (Rik) de
- Osterhaus, A.D.M.E. (Albert)
Publication date
January 2000
DOI Publisher
American Society for Microbiology ISSN
0022-538X Citation count (estimate)
41Abstract
Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV
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