The role of the ferric uptake regulator (Fur) in regulation of Helicobacter pylori iron uptake
- Vliet, A.H.M. (Arnoud) van
- Stoof, J. (Jeroen)
- Vlasblom, J.D. (Jan Dirk)
- Wainwright, S.A. (Stuart)
- Hughes, N.J. (Nicola)
- Kelly, D.J. (David)
- Bereswill, S. (Stefan)
- Bijlsma, J.J.E. (Jetta J.)
- Hoogenboezem, T. (Theo)
- Vandenbroucke-Grauls, C.M.J.E. (Christina)
- Kist, M. (Manfred)
- Kuipers, E.J. (Ernst)
- Kusters, J.G. (Johannes)
Publication date
August 2002
DOI Publisher
Wiley ISSN
1083-4389 Citation count (estimate)
83Abstract
Background. Availability of the essential nutrient iron is thought to vary greatly in the gastric mucosa, and thus the human gastric pathogen Helicobacter pylori requires regulatory responses to these environmental changes. Bacterial iron-responsive regulation is often mediated by Ferric Uptake Regulator (Fur) homologs, and in this study we have determined the role of H. pylori Fur in regulation of H. pylori iron uptake. Methods. Wild-type H. pylori and fur mutant derivatives were compared after growth in ironrestricted and iron-replete conditions. Iron-uptake was measured using 55Fe-labeled iron, whereas gene expression was mon
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