Phosphorescence-Fluorescence ratio imaging for monitoring the oxygen status during photodynamic therapy
- Sterenborg, H.J.C.M. (Dick)
- Wolf, J.W. (J.) de
- Koning, M. (Miriam)
- Kruijt, B. (Bastiaan)
- Ploeg-van den Heuvel, A. (Angélique) van der
- Robinson, D.J. (Dominic)
DOIAbstract
The effectiveness of photodynamic therapy is strongly dependent on the availabilty of oxygen. In the present paper we show that the ratio between photosensitiser phosphorescence and fluorescence is a parameter that can be used to monitor the competition between singlet oxygen production and other processes quenching the photosensitiser triplet state. We present a theoretical basis for the validity of this approach and a series of in vitro imaging experiments
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