Molecular mechanisms underlying variations in lung function: A systems genetics analysis
- Obeidat, M. (Ma'en)
- Hao, K. (Ke)
- Bossé, Y. (Yohan)
- Nickle, D.C. (David)
- Nie, Y. (Yunlong)
- Postma, D.S. (Dirkje)
- Laviolette, M. (Michel)
- Sandford, A. (Andrew)
- Daley, D. (Denise)
- Hogg, J.C. (James)
- Elliott, W.M.
- Fishbane, N. (Nick)
- Timens, W. (Wim)
- Hysi, P.G. (Pirro)
- Kaprio, J. (Jaakko)
- Wilson, J.F. (James F)
- Hui, J. (Jennie)
- Rawal, R. (Rajesh)
- Schulz, H. (Holger)
- Stubbe, B. (Beate)
- Hayward, C. (Caroline)
- Polasek, O. (Ozren)
- Jarvelin, M.-R. (Marjo-Riitta)
- Zhao, J.H. (Jing Hua)
- Jarvis, D.L. (Deborah L.)
- Kähönen, M. (Mika)
- Franceschini, N. (Nora)
- North, K.E. (Kari)
- Loth, D.W. (Daan)
- Brusselle, G.G. (Guy)
- Smith, A.V. (Davey)
- Gudnason, V. (Vilmundur)
- Bartz, T.M. (Traci M.)
- Wilk, J.B. (Jemma)
- O'Connor, G.T. (George)
- Cassano, P.A. (Patricia)
- Tang, W. (Wenbo)
- Wain, L.V. (Louise)
- Artigas, M.S.
- Gharib, S.A. (Sina)
- Strachan, D.P. (David P.)
- Sin, D.D.
- Tobin, M.D. (Martin)
- London, S.J. (Stephanie J.)
- Hall, I.P. (Ian)
- Paré, P.D. (Peter)
DOIAbstract
Background: Lung function measures reflect the physiological state of the lung, and are essential to the diagnosis of chronic obstructive pulmonary disease (COPD). The SpiroMeta-CHARGE consortium undertook the largest genome-wide association study (GWAS) so far (n=48 201) for forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) i
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