Streptococcus pneumoniae is a common cause of pneumonia and infective exacerbations of chronic lung disease, yet there are few data on how adaptive immunity can specifically prevent S. pneumoniae lung infection. We have used a murine model of nasopharyngeal colonization by the serotype 19F S. pneumoniae strain EF3030 followed by lung infection to investigate whether colonization protects against subsequent lung infection and the mechanisms involved. EF3030 colonization induced systemic and local immunoglobulin G against a limited number of S. pneumoniae protein antigens rather than capsular polysaccharide. During lung infection, previously colonized mice had increased early cytokine responses and neutrophil recruitment and reduced bacterial...
Streptococcus pneumoniae are bacteria that colonize the human upper respiratory tract. Although colo...
Streptococcus pneumoniae (Spn) is a common cause of respiratory infection, but also frequently colon...
SummaryStreptococcus pneumoniae is a leading cause of mortality in young children. While successful ...
textabstractStreptococcus pneumoniae is a common cause of pneumonia and infective exacerbations of c...
The nasopharyngeal commensal bacteria Streptococcus pneumoniae is also a frequent cause of serious i...
The nasopharyngeal commensal bacteria Streptococcus pneumoniae is also a frequent cause of serious i...
In this review we give an update on the mechanisms of naturally acquired immunity against Streptococ...
Acute lower respiratory tract infections are a persistent and pervasive public health burden, often ...
Streptococus pneumoniae is an important human pathogen, yet in most individuals it establishes only...
Live attenuated vaccines have been proposed as a strategy to induce protective immunity against infe...
Given that Streptococcus pneumoniae can cause life-threatening pulmonary and systemic infection, an ...
International audienceAcute pneumonia caused by Streptococcus pneumoniae is a major cause of child m...
Streptococcus pneumoniae is the major bacterial cause of community-acquired pneumonia, and the leadi...
Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase...
Nasopharyngeal colonization by Streptococcus pneumoniae constitutes a pre-requisite for development ...
Streptococcus pneumoniae are bacteria that colonize the human upper respiratory tract. Although colo...
Streptococcus pneumoniae (Spn) is a common cause of respiratory infection, but also frequently colon...
SummaryStreptococcus pneumoniae is a leading cause of mortality in young children. While successful ...
textabstractStreptococcus pneumoniae is a common cause of pneumonia and infective exacerbations of c...
The nasopharyngeal commensal bacteria Streptococcus pneumoniae is also a frequent cause of serious i...
The nasopharyngeal commensal bacteria Streptococcus pneumoniae is also a frequent cause of serious i...
In this review we give an update on the mechanisms of naturally acquired immunity against Streptococ...
Acute lower respiratory tract infections are a persistent and pervasive public health burden, often ...
Streptococus pneumoniae is an important human pathogen, yet in most individuals it establishes only...
Live attenuated vaccines have been proposed as a strategy to induce protective immunity against infe...
Given that Streptococcus pneumoniae can cause life-threatening pulmonary and systemic infection, an ...
International audienceAcute pneumonia caused by Streptococcus pneumoniae is a major cause of child m...
Streptococcus pneumoniae is the major bacterial cause of community-acquired pneumonia, and the leadi...
Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase...
Nasopharyngeal colonization by Streptococcus pneumoniae constitutes a pre-requisite for development ...
Streptococcus pneumoniae are bacteria that colonize the human upper respiratory tract. Although colo...
Streptococcus pneumoniae (Spn) is a common cause of respiratory infection, but also frequently colon...
SummaryStreptococcus pneumoniae is a leading cause of mortality in young children. While successful ...