IMPORTANCE: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD.We investigated whether the presence or absence of LBs correlates with different clinical features in LRRK2-related PD. OBSERVATIONS: We describe genetic, clinical, and neuropathological findings of 37 cases of LRRK2-related PD including 33 published and 4 unpublished cases through October 2013.Among the different mutations, the LRRK2 p.G2019S mutation was most f...
Background: Idiopathic Parkinson’s disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expecte...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
BACKGROUND: Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of P...
textabstractIMPORTANCE: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson dis...
Abstract Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most f...
AbstractWe have previously linked families with autosomal-dominant, late-onset parkinsonism to chrom...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Leucine-Rich Repeat Kinase 2 (LRRK2) gene mutations are the most common known cause of Parkinson's d...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Objective: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of Parkinson dis...
The G2019S leucine-rich repeat kinase 2 gene (LRRK2) mutation has been identified in a significant p...
Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions in leucin...
The identification of the leucine-rich repeat kinase 2 (LRRK2) gene was a breakthrough in the area o...
A clear pathologic hallmark like that identified in sporadic Parkinson’s disease (PD) is lacking in ...
Background: Idiopathic Parkinson’s disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expecte...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
BACKGROUND: Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of P...
textabstractIMPORTANCE: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson dis...
Abstract Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most f...
AbstractWe have previously linked families with autosomal-dominant, late-onset parkinsonism to chrom...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Leucine-Rich Repeat Kinase 2 (LRRK2) gene mutations are the most common known cause of Parkinson's d...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Objective: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of Parkinson dis...
The G2019S leucine-rich repeat kinase 2 gene (LRRK2) mutation has been identified in a significant p...
Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions in leucin...
The identification of the leucine-rich repeat kinase 2 (LRRK2) gene was a breakthrough in the area o...
A clear pathologic hallmark like that identified in sporadic Parkinson’s disease (PD) is lacking in ...
Background: Idiopathic Parkinson’s disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expecte...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
BACKGROUND: Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of P...