Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium
- Dehghan, A. (Abbas)
- Bis, J.C. (Joshua)
- White, C.C. (Charles)
- Smith, A.V. (Albert V.)
- Morrison, A.C. (Alanna)
- Cupples, L.A. (Adrienne)
- Trompet, S. (Stella)
- Chasman, D.I. (Daniel I.)
- Lumley, T. (Thomas)
- Völker, U. (Uwe)
- Buckley, B.M. (Brendan M.)
- Ding, J. (Jingzhong)
- Jensen, M.K. (Majken K.)
- Folsom, A.R. (Aaron R.)
- Kritchevsky, S.B. (Stephen)
- Girman, C.J. (Cynthia J.)
- Ford, I.
- Dörr, M. (Marcus)
- Salomaa, V. (Veikko)
- Uitterlinden, A.G. (André)
- Eiriksdottir, G. (Gudny)
- Vasan, R.S. (Ramachandran S.)
- Franceschini, N. (Nora)
- Carty, C. (Cara)
- Virtamo, J. (Jarmo)
- Demissie, S. (Serkalem)
- Amouyel, P. (Philippe)
- Arveiler, D. (Dominique)
- Heckbert, S.R. (Susan)
- Ferrieres, J. (Jean)
- Ducimetiere, P. (P.)
- Smith, N.L. (Nicholas)
- Wang, Y.A. (Ying)
- Siscovick, D.S. (David)
- Rice, K.M. (Kenneth)
- Wiklund, P.-G. (Per-Gunnar)
- Taylor, K.D. (Kent)
- Evans, A. (Alun)
- Kee, F. (Frank)
- Rotter, J.I. (Jerome I.)
- Karvanen, J. (Juha)
- Kuulasmaa, K. (Kari)
- Heiss, G. (Gerardo)
- Kraft, P. (Peter)
- Launer, L.J. (Lenore)
- Hofman, A. (Albert)
- Markus, M.R.P. (Marcello R.P.)
- Rose, L.M. (Lynda)
- Silander, K. (Kaisa)
- Wagner, P.J. (Peter)
- Benjamin, E.J. (Emelia)
- Lohman, K. (Kurt)
- Stott, D.J. (David. J.)
- Rivadeneira Ramirez, F. (Fernando)
- Harris, T.B. (Tamara)
- Levy, D. (Daniel)
- Liu, Y. (YongMei)
- Rimm, E.B. (Eric B.)
- Jukema, J.W. (Jan Wouter)
- Volzke, H. (Henry)
- Ridker, P.M. (Paul M.)
- Blankenberg, S. (Stefan)
- Franco, O.H. (Oscar)
- Gudnason, V. (Vilmundur)
- Psaty, B.M. (Bruce)
- Boerwinkle, E.A. (Eric)
- O'Donnell, C.J. (Christopher J.)
DOIAbstract
Background Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods We performed a two-stageGWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10-6 in Stage I were taken to Stage II for further discovery. Furthermore, in an analysis of prognosis, we studied whether known SNPs from former GWAS were associated with totalmortality in individuals who experienced MI during follow-up. Results In Stage I 15 loci passed the threshold of 5×10-6...
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