Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with insulin regulation is unknown in humans. Human adipocytes constitutively synthesize and secrete insulin, which is biologically functional. Insulin concentrations and release are fat mass-and LDs-dependent respectively. Fat reduction mediated by bariatric surgery repairs obesity-associated T2D the expression of genes, like PCSK1 (proinsulin conversion enzyme), GCG (Glucagon), GPLD1, CD38 and NNAT, involved in insulin regulation/release were differentially expressed in pancreas and adipose tissue (AT). INS (insulin) and GCG e...
Obesity has reached epidemic proportions worldwide and is associated with insulin resistance, type 2...
Insulin resistance is one of the pathophysiological features of obesity and type 2 diabetes. Recent ...
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence i...
Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunct...
Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunct...
Contains fulltext : 153283.pdf (publisher's version ) (Open Access)Lipid droplets ...
Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunct...
International audienceMetabolic disorders related to obesity are largely dependent on adipose tissue...
Pancreatic beta-cells regulate blood glucose by secreting insulin in response to nutrients. The deve...
Pancreatic ß-cell function is of critical importance in the regulation of fuel homoeostasis, and met...
Obesity, especially visceral fat accumulation, increases the risk of type 2 diabetes (T2D). The purp...
The type 2 diabetes pandemic in recent decades is a huge global health threat. This pandemic is prim...
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence i...
Obesity strongly predisposes to the development of type 2 diabetes (T2D) as well as a myriad of meta...
Background: It is now generally accepted that obesity is a major risk factor for type 2 diabetes mel...
Obesity has reached epidemic proportions worldwide and is associated with insulin resistance, type 2...
Insulin resistance is one of the pathophysiological features of obesity and type 2 diabetes. Recent ...
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence i...
Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunct...
Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunct...
Contains fulltext : 153283.pdf (publisher's version ) (Open Access)Lipid droplets ...
Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunct...
International audienceMetabolic disorders related to obesity are largely dependent on adipose tissue...
Pancreatic beta-cells regulate blood glucose by secreting insulin in response to nutrients. The deve...
Pancreatic ß-cell function is of critical importance in the regulation of fuel homoeostasis, and met...
Obesity, especially visceral fat accumulation, increases the risk of type 2 diabetes (T2D). The purp...
The type 2 diabetes pandemic in recent decades is a huge global health threat. This pandemic is prim...
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence i...
Obesity strongly predisposes to the development of type 2 diabetes (T2D) as well as a myriad of meta...
Background: It is now generally accepted that obesity is a major risk factor for type 2 diabetes mel...
Obesity has reached epidemic proportions worldwide and is associated with insulin resistance, type 2...
Insulin resistance is one of the pathophysiological features of obesity and type 2 diabetes. Recent ...
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence i...