Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia
- Linden, M.H. (Marieke) van der
- Seslija, L. (Lidija)
- Schneider, P. (Pauline)
- Driessen, E.M.C. (Emma)
- Castro, P.G. (Patricia Garrido)
- Stumpel, D.J.P.M. (Dominique)
- Roon, E.H.J. (Eddy) van
- Boer, J.B. (Josien) de
- Williams, O. (Odette)
- Pieters, R. (Rob)
- Stam, R.W. (Ronald)
DOIAbstract
MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (<1 year) is characterized by high relapse rates and a dismal prognosis. To facilitate the discovery of novel therapeutic targets, we here searched for genes directly influenced by the repression of various MLL fusions. Methods For this, we performed gene expression profiling after siRNA-mediated repression of MLLAF4, MLL-ENL, and AF4-MLL in MLL -rearranged ALL cell line models. The obtained results were compared with various already established gene signatures including those consisting of known MLL-AF4 target genes, or those associated with primary MLL-rearranged infant ALL samples. Results Genes that were down-regulated in response to the repression of MLL-AF4 and MLL-ENL appea...
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