Biomarkers for circadian rhythm disruption independent of time of day
- Dycke, K.C.G. (Kirsten) van
- Pennings, J.L.A. (Jeroen L.A.)
- Oostrom, C.T.M. (Conny) van
- Van Kerkhof, L.W.M. (Linda W.M.)
- Steeg, H. (Harry) van
- Horst, G.T.J. (Gijsbertus) van der
- Rodenburg, W. (Wendy)
DOIAbstract
Frequent shift work causes disruption of the circadian rhythm and might on the long-term result in increased health risk. Current biomarkers evaluating the presence of circadian rhythm disturbance (CRD), including melatonin, cortisol and body temperature, require 24-hr ("around the clock") measurements, which is tedious. Therefore, these markers are not eligible to be used in large-scale (human) studies.
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