Clinical characterization of familial isolated pituitary adenomas
- Daly, A.F. (Adrian)
- Jaffrain-Rea, M-L. (Marie-Lise)
- Ciccarelli, E. (Enrica)
- Valdes-Socin, H. (H.)
- Rohmer, V. (Vincent)
- Tamburrano, G. (Guido)
- Borson-Chazot, F. (Francoise)
- Estour, B. (Bruno)
- Ciccarelli, E. (Enrica)
- Brue, T. (Thierry)
- Ferolla, P. (Piero)
- Emy, P. (Philippe)
- Colao, A. (Annamaria)
- Menis, E. (Ernesto) de
- Lecomte, P. (Pierre)
- Penfornis, A. (Alfred)
- Delemer, B. (B.)
- Bertherat, J. (Jerome)
- Wémeau, J.L.
- Herder, W.W. (Wouter) de
- Archambeaud, F. (Françoise)
- Stevenaert, A. (A.)
- Calender, A. (Alain)
- Murat, A. (Arnaud)
- Cavagnini, F. (Francesco)
- Beckers, A. (Albert)
DOIAbstract
Context: Familial pituitary adenomas occur rarely in the absence of multiple endocrine neoplasia type 1(MEN1)and Carney complex (CNC). Objective: Our objective was to characterize the clinical and genealogical features of non-MEN1/CNC familial isolated pituitary adenomas (FIPA). Design and Setting: We conducted a retrospective study of clinical and genealogical characteristics of FIPA cases and performed a comparison with a sporadic population at 22 university hospitals in Belgium, Italy, France, and The Netherlands. Results: Sixty-four FIPA families including 138 affected individuals were identified [55 prolactinomas, 47 somatotropinomas, 28 nonsecreting adenomas (NS), and eight ACTH-s
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