Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a process which entails reciprocal exchange of soluble signals between tumor cells and their osseous microenvironment. Recent evidence indicates that tumor-intrinsic miRNAs are pleiotropic regulators of gene expression. But they are also frequently released in exosome-like vesicles (ELV). Yet the functional relevance of the transference of tumor-derived ELV and their miRNA cargo to the extracellular milieu during osseous colonization is unknown. Comparative transcriptomic profiling using an in vivo murine model of bone metastasis identified a...
The occurrence of osteosarcoma (OS) is associated with abnormal expression of many microRNAs (miRNAs...
International audienceThe metastatic dissemination is a complex multistep process by which tumor cel...
International audienceThe metastatic dissemination is a complex multistep process by which tumor cel...
et al.Bone metastasis represents one of the most deleterious clinical consequences arising in the co...
Bone microenvironment provides growth and survival signals essential for osteosarcoma (OS) initiatio...
In the UK in 2016, prostate cancer was the most commonly diagnosed cancer in men and it is the fifth...
Prostate cancer (PCa) is the most frequent malignancy in older men with a high propensity for bone m...
Prostate cancer (PCa) is the most frequent malignancy in older men with a high propensity for bone m...
Osteosarcoma is the most common primary bone tumor during childhood and adolescence. Several reports...
The development of bone metastases requires multistep and multicellular machinery consisting not onl...
The development of bone metastases requires multistep and multicellular machinery consisting not onl...
Abstract Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely prese...
The development of bone metastases requires multistep and multicellular machinery consisting not onl...
AbstractTumor exosomes educate selected host tissues toward a prometastatic phenotype. We demonstrat...
Bone metastasis represents one of the most devastating consequences of lung cancer associated with p...
The occurrence of osteosarcoma (OS) is associated with abnormal expression of many microRNAs (miRNAs...
International audienceThe metastatic dissemination is a complex multistep process by which tumor cel...
International audienceThe metastatic dissemination is a complex multistep process by which tumor cel...
et al.Bone metastasis represents one of the most deleterious clinical consequences arising in the co...
Bone microenvironment provides growth and survival signals essential for osteosarcoma (OS) initiatio...
In the UK in 2016, prostate cancer was the most commonly diagnosed cancer in men and it is the fifth...
Prostate cancer (PCa) is the most frequent malignancy in older men with a high propensity for bone m...
Prostate cancer (PCa) is the most frequent malignancy in older men with a high propensity for bone m...
Osteosarcoma is the most common primary bone tumor during childhood and adolescence. Several reports...
The development of bone metastases requires multistep and multicellular machinery consisting not onl...
The development of bone metastases requires multistep and multicellular machinery consisting not onl...
Abstract Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely prese...
The development of bone metastases requires multistep and multicellular machinery consisting not onl...
AbstractTumor exosomes educate selected host tissues toward a prometastatic phenotype. We demonstrat...
Bone metastasis represents one of the most devastating consequences of lung cancer associated with p...
The occurrence of osteosarcoma (OS) is associated with abnormal expression of many microRNAs (miRNAs...
International audienceThe metastatic dissemination is a complex multistep process by which tumor cel...
International audienceThe metastatic dissemination is a complex multistep process by which tumor cel...