Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation
- Mohty, M.
- Malard, F.
- Abecassis, M.
- Aerts, E.
- Alaskar, AS.
- Aljurf, M.
- Bader, P
- Baron, Frédéric
- Bazarbachi, A.
- Blaise, D.
- Ciceri, F.
- Corbacioglu, S.
- Dalle, JH.
- Dignan, F.
- Fukuda, T.
- Huynh, A.
- Masszi, T.
- Michallet, M.
- Nagler, A.
- NiChoghaile, M.
- Okamoto, S.
- Pagliuca, A.
- Peters, C.
- Petersen, FB.
- Richardson, PG.
- Ruutu, T.
- Savani, BN.
- Wallhult, E.
- Yakoub-Agha, I.
- Duarte, RF.
- Carreras, E.
DOIAbstract
peer reviewedSinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (480%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for...
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