The expansion of hMSC adhered on microcarriers is a proven technology to allow the production of quantitatively (cell density and growth rate) and qualitatively (preservation of cell stemness) the amounts of cells required for clinical applications. In that context of process optimization, a platform of 6 parallel 250 mL stirred minibioreactors have been designed and fully equipped for hMSC cultivation on microcarriers. The local hydrodynamics in these bioreactors have been characterized using CFD simulations and experimental measurements. GOALS: 1) Evaluation of the flexibility of the platform for extensively studying the coupling between hydrodynamics and hMSC physiological response (growth, stemness) by changing agitation conditions. ...
The manufacture of a new drug requires process development at the early stage in the development cyc...
Abstract The scale-up of animal cell cultivation is important but remains complex and challenging. I...
Interest for microcarrier-based processes for the large-scale culture of adherent cells has recently...
The potential of human mesenchymal stem cells (hMSCs) for allogeneic cell therapies has created a la...
Monoclonal antibodies are biomolecules that are able to bind to a specific antigen. Antibodies are i...
Hydrodynamic variables in bioreactors such as velocity, shear rate, and energy dissipation rate have...
The use of computational fluid dynamics (CFD) techniques can be used to develop and/or optimize a sc...
Embryonic stem cells have a large potential to help patients with commonly known diseases such as Pa...
The ambr250 unit is a fully automated disposable 100-250 ml bioreactor for R&D that has been develop...
Bioreactor design is a challenging endeavour that aims to provide the most ideal environment in whic...
Over the last decade especially, the promise of stem cell technology to cure a multitude of genetic ...
Mammalian cells have been widely used to produce therapeutic proteins in stirred bioreactors in susp...
CFD (computational fluid dynamics) is becoming a common and practical tool for modeling the hydrodyn...
Computational Fluid Dynamics (CFD) is an established method in fluid mechanics that allows fluidic p...
There is a growing necessity for cell cultivation using bioreactors to translate laboratory based cu...
The manufacture of a new drug requires process development at the early stage in the development cyc...
Abstract The scale-up of animal cell cultivation is important but remains complex and challenging. I...
Interest for microcarrier-based processes for the large-scale culture of adherent cells has recently...
The potential of human mesenchymal stem cells (hMSCs) for allogeneic cell therapies has created a la...
Monoclonal antibodies are biomolecules that are able to bind to a specific antigen. Antibodies are i...
Hydrodynamic variables in bioreactors such as velocity, shear rate, and energy dissipation rate have...
The use of computational fluid dynamics (CFD) techniques can be used to develop and/or optimize a sc...
Embryonic stem cells have a large potential to help patients with commonly known diseases such as Pa...
The ambr250 unit is a fully automated disposable 100-250 ml bioreactor for R&D that has been develop...
Bioreactor design is a challenging endeavour that aims to provide the most ideal environment in whic...
Over the last decade especially, the promise of stem cell technology to cure a multitude of genetic ...
Mammalian cells have been widely used to produce therapeutic proteins in stirred bioreactors in susp...
CFD (computational fluid dynamics) is becoming a common and practical tool for modeling the hydrodyn...
Computational Fluid Dynamics (CFD) is an established method in fluid mechanics that allows fluidic p...
There is a growing necessity for cell cultivation using bioreactors to translate laboratory based cu...
The manufacture of a new drug requires process development at the early stage in the development cyc...
Abstract The scale-up of animal cell cultivation is important but remains complex and challenging. I...
Interest for microcarrier-based processes for the large-scale culture of adherent cells has recently...
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