Anatomo-clinical atlases in subthalamic Deep Brain Stimulation correlating clinical data and electrode contacts coordinates

Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS) electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital Atlases gathering patient's location of electrode contacts and clinical scores. Our anatomo-clinical atlases were assessed using non-supervised classification to extract clusters and create rules for finding the optimum site for therapeutic STN DBS