International audienceSoftware and hardware co-design and optimization of HPC systems has become intolerably complex, ad-hoc, time consuming and error prone due to enormous number of available design and optimization choices, complex interactions between all software and hardware components, and multiple strict requirements placed on performance, power consumption, size, reliability and cost. We present our novel long-term holistic and practical solution to this problem based on customizable, plugin-based, schema-free, heterogeneous, open-source Collective Mind repository and infrastructure with unified web interfaces and on-line advise system. This collaborative framework distributes analysis and multi-objective off-line and on-line auto-t...