International audienceThe Mediterranean region is a climate change hotspot where the rate of climate change exceeds the global mean. The rapidly changing climate in combination with an increase in anthropogenic pressures cause water resources in the Mediterranean basin to become increasingly scarce. Modelling future water resource availability considering both climate and anthropogenic changes on karst catchments remains a major challenge in the field of hydrology. The purpose of this study is to assess the relative effects of climate change and anthropogenic forcing on the spring discharge of a Mediterranean karst system by coupling 12 climate model simulations under two emission scenarios (RCP 4.5 and RCP 8.5) with three hydrological mode...