Oral transmission of L-type bovine spongiform encephalopathy in primate model.
- Frances, Nadine
- Nicot, Simon
- Rouland, Sylvie
- Biacabe, Anne-Gaëlle
- Quadrio, Isabelle
- Perret-Liaudet, Armand
- Baron, Thierry
- Verdier, Jean-Michel
Publication date
January 2012
DOI Publisher
Centers for Disease Control and PreventionAbstract
International audienceWe report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue. After neurologic symptoms appeared, transmissibility of the disease by both inoculation routes was confirmed by detection of disease-associated prion protein in samples of brain tissue
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