An aminocatalyzed michael addition/iron-mediated decarboxylative cyclization sequence for the preparation of 2,3,4,6-tetrasubstituted pyridines: scope and mechanistic insights

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQA novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization e82191031910330FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ2015/20809-4, 2016/12749-4, 2015/01331-6, 2014/15718-7458416/2014-2, 162191/2015-4M.L.S. acknowledges Faepex-Unicamp for an M. Sc. fellowship (127/16). The authors are grateful to Fapesp for a research grant to I.D.J. (2015/20809-4) and B. Sc. fellowships to M.D. (2016/12749-4), C.S. (2015/01331-6), and N.M.R.C. (2014/15718-7). CNPq i