Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
- Michael Prattes
- Irina Grishkovskaya
- Victor-Valentin Hodirnau
- Ingrid Rössler
- Isabella Klein
- Christina Hetzmannseder
- Gertrude Zisser
- Christian C. Gruber
- Karl Gruber
- David Haselbach
- Helmut Bergler
Publication date
June 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into the mechanism of inhibition and specificity of this class of inhibitors
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