Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
- Kim Valette
- Zhonglin Li
- Valentin Bon-Baret
- Arnaud Chignon
- Jean-Christophe Bérubé
- Aida Eslami
- Jennifer Lamothe
- Nathalie Gaudreault
- Philippe Joubert
- Ma’en Obeidat
- Maarten van den Berge
- Wim Timens
- Don D. Sin
- David C. Nickle
- Ke Hao
- Catherine Labbé
- Krystelle Godbout
- Andréanne Côté
- Michel Laviolette
- Louis-Philippe Boulet
- Patrick Mathieu
- Sébastien Thériault
- Yohan Bossé
Publication date
June 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Communications BiologyAbstract
Kim Valette et al. perform a genomic study on asthma integrating genome-wide association study, functional mapping using lung and blood transcriptome-wide profiles, as well as Mendelian randomization. They show candidate causal genes expressed in lung and blood tissues that are putative therapeutic targets for asthma
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