Mycobacterium tuberculosis induces metabolic reprogramming in macrophages like the Warburg effect. This enhances antimicrobial performance at the expense of increased inflammation, which may promote a pathogen-permissive host environment. Since the NAD(+)-dependent protein deacetylase Sirtuin 3 (SIRT3) is an important regulator of mitochondrial metabolism and cellular redox homeostasis, we hypothesized that SIRT3 modulation mediates M. tuberculosis-induced metabolic reprogramming. Infection of immortalized and primary murine macrophages resulted in reduced levels of SIRT3 mRNA and protein and perturbation of SIRT3-regulated enzymes in the tricarboxylic acid cycle, electron transport chain, and glycolytic pathway. These changes were associat...
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathwa...
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathwa...
Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and ...
SIRT3 (sirtuin 3), a mitochondrial protein deacetylase, maintains respiratory function, but its role...
Macrophage activation involves metabolic reprogramming to support antimicrobial cellular functions. ...
Mycobacterium tuberculosis (Mtb) executes a plethora of immune-evasive mechanisms, which contribute ...
Macrophages are the main target cells for Mycobacterium tuberculosis (Mtb) infection. Previous studi...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
ABSTRACT Macrophage activation involves metabolic reprogramming to support antimicrobial cellular fu...
The pathogenic success of Mycobacterium tuberculosis (Mtb) is tightly linked to its ability to recal...
Mycobacterium tuberculosis (Mtb) is the leading infectious disease killer worldwide. We discovered t...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
Abstract Background Mitophagy, mitochondrial selective autophagy, plays a pivotal role in the mainte...
ABSTRACT Macrophages are the primary targets of Mycobacterium tuberculosis infection; the early even...
Pulmonary macrophages have two distinct ontogenies: long-lived embryonically-seeded alveolar macroph...
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathwa...
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathwa...
Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and ...
SIRT3 (sirtuin 3), a mitochondrial protein deacetylase, maintains respiratory function, but its role...
Macrophage activation involves metabolic reprogramming to support antimicrobial cellular functions. ...
Mycobacterium tuberculosis (Mtb) executes a plethora of immune-evasive mechanisms, which contribute ...
Macrophages are the main target cells for Mycobacterium tuberculosis (Mtb) infection. Previous studi...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
ABSTRACT Macrophage activation involves metabolic reprogramming to support antimicrobial cellular fu...
The pathogenic success of Mycobacterium tuberculosis (Mtb) is tightly linked to its ability to recal...
Mycobacterium tuberculosis (Mtb) is the leading infectious disease killer worldwide. We discovered t...
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox h...
Abstract Background Mitophagy, mitochondrial selective autophagy, plays a pivotal role in the mainte...
ABSTRACT Macrophages are the primary targets of Mycobacterium tuberculosis infection; the early even...
Pulmonary macrophages have two distinct ontogenies: long-lived embryonically-seeded alveolar macroph...
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathwa...
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathwa...
Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and ...