Motivation: Monoclonal antibody therapeutics are often produced from non-human sources (typically murine), and can therefore generate immunogenic responses in humans. Humanization procedures aim to produce antibody therapeutics that do not elicit an immune response and are safe for human use, without impacting efficacy. Humanization is normally carried out in a largely trial-and-error experimental process. We have built machine learning classifiers that can discriminate between human and non-human antibody variable domain sequences using the large amount of repertoire data now available. Results: Our classifiers consistently outperform the current best-in-class model for distinguishing human from murine sequences, and our output scores exh...
Despite their utility as models for human systems, intrinsic differences between mouse and human bio...
In antibody humanization, complementarity determining regions from a 'donor' antibody are often graf...
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs) are tremend...
Abstract Antibody humanization is a key step in the preclinical phase of the development of therapeu...
Summary: Antibodies are rapidly becoming essential tools in the clin-ical practice, given their abil...
Summary: Antibodies are rapidly becoming essential tools in the clin-ical practice, given their abil...
Monoclonal antibodies (mAbs) have revolutionized medicine in the last 20 years and today represents ...
Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to re...
The optimization of therapeutic antibodies is time-intensive and resource-demanding, largely because...
MOTIVATION: The precise targeting of antibodies and other protein therapeutics is required for their...
<div><p>1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and deli...
Immunogenicity is an important concern for therapeutic antibodies during drug development. By analyz...
Monoclonal antibodies (mAbs) are widely used due to their exquisite specificity and once were hailed...
Generative machine learning (ML) has been postulated to become a major driver in the computational d...
Antibodies are natural proteins that are central to the function of the immune system. With high aff...
Despite their utility as models for human systems, intrinsic differences between mouse and human bio...
In antibody humanization, complementarity determining regions from a 'donor' antibody are often graf...
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs) are tremend...
Abstract Antibody humanization is a key step in the preclinical phase of the development of therapeu...
Summary: Antibodies are rapidly becoming essential tools in the clin-ical practice, given their abil...
Summary: Antibodies are rapidly becoming essential tools in the clin-ical practice, given their abil...
Monoclonal antibodies (mAbs) have revolutionized medicine in the last 20 years and today represents ...
Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to re...
The optimization of therapeutic antibodies is time-intensive and resource-demanding, largely because...
MOTIVATION: The precise targeting of antibodies and other protein therapeutics is required for their...
<div><p>1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and deli...
Immunogenicity is an important concern for therapeutic antibodies during drug development. By analyz...
Monoclonal antibodies (mAbs) are widely used due to their exquisite specificity and once were hailed...
Generative machine learning (ML) has been postulated to become a major driver in the computational d...
Antibodies are natural proteins that are central to the function of the immune system. With high aff...
Despite their utility as models for human systems, intrinsic differences between mouse and human bio...
In antibody humanization, complementarity determining regions from a 'donor' antibody are often graf...
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs) are tremend...