Background: Metagenomic sequencing is frequently claimed to have the potential to revolutionise microbiology through rapid species identification and antimicrobial resistance (AMR) prediction. We assess progress towards this. Methods: We perform a systematic review and meta-analysis of all published literature on culture-independent metagenomic sequencing for pathogen-agnostic infectious disease diagnostics to August 12, 2020. Methodologic bias and applicability were assessed using QUADAS-2. (PROSPERO CRD42020163777) Results: A total of 2023 clinical samples from 13/21 eligible diagnostic test accuracy studies were included in the meta-analysis. Reference standards were culture, molecular testing, clinical decision or a composite measure....
<div><p>With the decreasing cost of next-generation sequencing, deep sequencing of clinical samples ...
The identification of microbiological infection is usually a diagnostic investigation, a complex pro...
Abstract Background Infectious disease is the leading cause of death worldwide, and diagnosis of pol...
INTRODUCTION: Rapid and sensitive diagnostic strategies are necessary for patient care and public he...
Whole genome sequencing (WGS) plays an increasing role in communicable disease control through high-...
INTRODUCTIONWith established applications of next-generation sequencing in inherited diseases and on...
Traditional microbial detection methods have difficulty meeting the needs of pathogen detection in t...
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach fo...
The term ‘shotgun metagenomics ’ is applied to the direct sequencing of DNA extracted from a sample ...
BackgroundThe aim of this study is to compare the diagnostic value of metagenomic next-generation se...
BackgroundThe aim of this study is to compare the diagnostic value of metagenomic next-generation se...
With the decreasing cost of next-generation sequencing, deep sequencing of clinical samples provides...
CONTEXT: - Metagenomic sequencing can be used for detection of any pathogens using unbiased, shotgun...
Clinical metagenomics (CMg) is the discipline that refers to the sequencing of all nucleic acid mate...
BackgroundThe aim of this study is to compare the diagnostic value of metagenomic next-generation se...
<div><p>With the decreasing cost of next-generation sequencing, deep sequencing of clinical samples ...
The identification of microbiological infection is usually a diagnostic investigation, a complex pro...
Abstract Background Infectious disease is the leading cause of death worldwide, and diagnosis of pol...
INTRODUCTION: Rapid and sensitive diagnostic strategies are necessary for patient care and public he...
Whole genome sequencing (WGS) plays an increasing role in communicable disease control through high-...
INTRODUCTIONWith established applications of next-generation sequencing in inherited diseases and on...
Traditional microbial detection methods have difficulty meeting the needs of pathogen detection in t...
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach fo...
The term ‘shotgun metagenomics ’ is applied to the direct sequencing of DNA extracted from a sample ...
BackgroundThe aim of this study is to compare the diagnostic value of metagenomic next-generation se...
BackgroundThe aim of this study is to compare the diagnostic value of metagenomic next-generation se...
With the decreasing cost of next-generation sequencing, deep sequencing of clinical samples provides...
CONTEXT: - Metagenomic sequencing can be used for detection of any pathogens using unbiased, shotgun...
Clinical metagenomics (CMg) is the discipline that refers to the sequencing of all nucleic acid mate...
BackgroundThe aim of this study is to compare the diagnostic value of metagenomic next-generation se...
<div><p>With the decreasing cost of next-generation sequencing, deep sequencing of clinical samples ...
The identification of microbiological infection is usually a diagnostic investigation, a complex pro...
Abstract Background Infectious disease is the leading cause of death worldwide, and diagnosis of pol...