Neuroblastoma is a childhood extracranial solid tumor which is associated with a number of genetic changes. Included in these genetic alterations are mutations in the kinase domain of the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase (RTK), which have been found in both somatic and familial neuroblastoma. In order to treat patients accordingly required characterisation of these mutations in terms of their response to ALK tyrosine kinase inhibitors (TKIs). Here, we report the identification and characterisation of two novel neuroblastoma ALK mutations (A1099T and 1464STOP) which we have investigated together with several previously reported but uncharacterised ALK mutations (T1087I, D1091N, T1151M, M1166R, F1174I and A1234T). In ...
In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated ...
Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed d...
Neuroblastoma (NB) is the most common and deadly solid tumour in children. Despite the development o...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion p...
Activating mutations in the kinase domain of anaplastic lymphoma kinase (ALK) have recently been sho...
AbstractActivating mutations in the kinase domain of anaplastic lymphoma kinase (ALK) have recently ...
The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially ...
Numerous mutations have been observed in the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kina...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the family of insulin re...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK), which is transiently expressed...
Activating mutations in the anaplastic lymphoma kinase (ALK) gene were recently discovered in neurob...
SummaryGenetic studies have established anaplastic lymphoma kinase (ALK), a cell surface receptor ty...
Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is largely unkn...
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is a clinical target of major in...
Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most familial and 10...
In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated ...
Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed d...
Neuroblastoma (NB) is the most common and deadly solid tumour in children. Despite the development o...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion p...
Activating mutations in the kinase domain of anaplastic lymphoma kinase (ALK) have recently been sho...
AbstractActivating mutations in the kinase domain of anaplastic lymphoma kinase (ALK) have recently ...
The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially ...
Numerous mutations have been observed in the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kina...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the family of insulin re...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK), which is transiently expressed...
Activating mutations in the anaplastic lymphoma kinase (ALK) gene were recently discovered in neurob...
SummaryGenetic studies have established anaplastic lymphoma kinase (ALK), a cell surface receptor ty...
Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is largely unkn...
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is a clinical target of major in...
Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most familial and 10...
In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated ...
Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed d...
Neuroblastoma (NB) is the most common and deadly solid tumour in children. Despite the development o...