Associations of Estrogen Receptor, Progesterone Receptor, Human Epidemic Growth Factor Receptor-2 and Ki-67 with Ultrasound Signs and Prognosis of Breast Cancer Patients

Xingjuan Zhao,1 Xuan Yang,1 Lei Fu,2 Keda Yu3 1Department of Mammary Gland, Shanxi People’s Hospital, Taiyuan City, Shanxi Province, 030000, People’s Republic of China; 2Department of Surgery, Shanxi Provincial General Team Hospital of the Chinese People’s Armed Police Force, Taiyuan City, Shanxi Province, 030000, People’s Republic of China; 3Department of Mammary Gland, Fudan University Cancer Hospital, Taiyuan City, Shanxi Province, 030000, People’s Republic of ChinaCorrespondence: Xingjuan ZhaoDepartment of Mammary Gland, Shanxi People’s Hospital, No. 29 Shuangtasi Street, Taiyuan City, Shanxi Province, 030000, People’s Republic of ChinaEmail zhaoxingjuan2020@163.comObjective: The functions of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 in breast cancer have been explored. This study was carried out to explore ER, PR, HER-2 and Ki-67 expression levels in breast cancer patients and their relationship with ultrasound signs and prognosis.Patients and Methods: A total of 274 female primary breast cancer patients received preoperative ultrasound examination. ER, PR, HER-2 and Ki-67 expression levels in breast cancer tissues were detected by immunohistochemical staining after surgery. The correlations of ER, PR, HER-2 and Ki-67 expression with ultrasound signs and prognosis of breast cancer patients were analyzed.Results: The positive expression rate of ER, PR and HER-2 and Ki-67 high expression in 274 breast cancer patients was 73.36% (201/274), 59.85% (164/274), 24.09% (66/274) and 66.06% (181/274), respectively. ER-positive expression had association with lymph node metastasis (LNM) and blood flow grading; HER-2-positive expression was associated with LNM, while Ki-67-positive expression was related to the tumor diameter, LNM, and blood flow grading. LNM and Ki-67 high expression were risk factors for OS; PR-positive was a protective factor for OS; TNM stage, tumor diameter, LNM and Ki-67 high expression were risk factors for DFS in breast cancer patients.Conclusion: ER, PR, HER-2 and Ki-67 in breast cancer are related to the ultrasound signs and prognosis of breast cancer patients. The joint detection of multiple indicators provides a reference for the individualized treatment of targeted drugs.Keywords: estrogen receptor, progesterone receptor, human epidemic growth factor receptor-2, Ki-67, breast cancer, ultrasound signs, prognosi