BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR). METHODS AND FINDINGS: We used SNPs associated with each risk factor as instrumental variables in MR analyses. We considered type 2 diabetes (T2D, NSNPs = 49), fasting glucose (NSNPs = 36), insulin resistance (NSNPs = 10), body mass index (BMI, NSNPs = 32), total cholesterol (NSNPs = 73), HDL-cholesterol (NSNPs = 71), LDL-cholesterol (NSNPs = 57), triglycerides (NSNPs = 39), systolic blood pressure ...
BACKGROUND: Dementia incidence is increasing across the globe and currently there are no disease-mod...
OBJECTIVE To determine which potentially modifiable risk factors, including socioeconomic, lifestyle...
Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk factors thr...
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoki...
Background Potentially modifiable risk factors including obesity, diabetes, hypertension, and smokin...
BackgroundPotentially modifiable risk factors including obesity, diabetes, hypertension, and smoking...
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoki...
<div><p>Background</p><p>Potentially modifiable risk factors including obesity, diabetes, hypertensi...
BACKGROUND: Alzheimer 's disease (AD) is highly prevalent in the global population, predicted to aff...
IMPORTANCE An estimated 40% of dementia is potentially preventable by modifying 12 risk factors thro...
Importance: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors thr...
Background Considerable uncertainty remains regarding associations of multiple risk factors with Al...
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyl...
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyl...
Observational research shows that higher body mass index (BMI) increases Alzheimer's disease (AD) ri...
BACKGROUND: Dementia incidence is increasing across the globe and currently there are no disease-mod...
OBJECTIVE To determine which potentially modifiable risk factors, including socioeconomic, lifestyle...
Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk factors thr...
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoki...
Background Potentially modifiable risk factors including obesity, diabetes, hypertension, and smokin...
BackgroundPotentially modifiable risk factors including obesity, diabetes, hypertension, and smoking...
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoki...
<div><p>Background</p><p>Potentially modifiable risk factors including obesity, diabetes, hypertensi...
BACKGROUND: Alzheimer 's disease (AD) is highly prevalent in the global population, predicted to aff...
IMPORTANCE An estimated 40% of dementia is potentially preventable by modifying 12 risk factors thro...
Importance: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors thr...
Background Considerable uncertainty remains regarding associations of multiple risk factors with Al...
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyl...
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyl...
Observational research shows that higher body mass index (BMI) increases Alzheimer's disease (AD) ri...
BACKGROUND: Dementia incidence is increasing across the globe and currently there are no disease-mod...
OBJECTIVE To determine which potentially modifiable risk factors, including socioeconomic, lifestyle...
Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk factors thr...