Pregnancy rate in patients with early-stage cervical cancer after conservative surgical treatment, meta-analysis

Introduction: Cervical cancer is the fourth most common type of cancer worldwide and is the third leading cause of death in women. Conservative surgical treatment, that preserves menstrual function and fertility, has become a standard for young women, especially nulliparous women, with early-stage disease. Worldwide, of all patients operated on by radical trachealectomy with or without lymphadenectomy, 60% of pregnancies were full-term pregnancies. The aim of this study was to study the pregnancy rate in patients with early-stage cervical cancer after conservative surgical treatment. Materials and methods: is a meta-analysis study that included 20 clinical trials, a total of 4,568 cervical cancer patients undergoing conservative surgical treatment. Three studies focused on conservative surgical treatment by conization of the cervix or LLETZ in 946 cases and 17 studies reported with radical tracheectomy with or without pelvic lymphadenectomy in 3622 patients. Results: out of the 20 articles studied, in 4 no fertility rates were reported, and based on the 16 papers it was shown that the patients who tried to get pregnant was 31.2%, those pregnant were 58.4 % and the term birth rate being 58.6%. Patients with a premature birth rate is 25.7%, miscarriage in the first trimester was 13.1% and in the second trimester it was 7,2%. The term births were 20.8%. Women who managed to get pregnant with ggive birth to alive babies accounted for 58.6%. Conclusions: Patients with conization (LLETZ) have a lower rate of miscarriage and premature birth, caused by limited trauma to the cervix and parameter. Trahelectomy with or without pelvic lymphadenectomy may be a suitable option for pregnancy, followed by uterine cerclage throughout pregnancy. Women who managed to get pregnant and giving birth to alive babies was 58.6%