Уровень интерлейкинов у детей с острыми бронхообструктивными заболеваниями микоплазменной этиологии

USMF “Nicolae Testemiţanu”, Departamentul PediatrieAim of our study was to evaluate changes of the interleukin 2 (IL-2) and interleukin 4 (IL-4) in the peripheral blood of children with Mycoplasma pneumoniae bronhoobstructive diseases. Material and Methods. The study included 33 children, aged 6 months - 7 years, with pneumonia and wheezing. Changes of IL-2 and IL-4 in peripheral blood in acute Mycoplasma pneumoniae infection were evaluated. Levels of Mycoplasma pneumoniae-specific antibodies (IgM, IgG), the peripheral blood concentrations of IL-2 and IL-4 were determined in serum samples obtained at enrollment from all 33 children that were tested by ELISA. Results. There were two study visits: first at admission and the second one – after 1 month. Twenty patients completed the study group with Mycoplasma-positive infection and 13 children completed the control group - Mycoplasmanegative infection. IL-2 levels in children with Mycoplasma-positive bronchopulmonary disease was 31,80±2,26 pg/ ml and in Mycoplasma-negative group 39,27±3,17 pg/ml, IL-4 levels was 46,92±2,93 pg/ml versus 52,36±2,17pg/ml, respectively. After 1 month in Mycoplasma-positive group IL-2 levels had increased (39,68±6,84pg/ml). No significant changes were observed for IL-4 values in the period of one month after the admission (47,75±2,19 pg/ml). Conclusion. There was observed an imbalance of the immune response with significant decrease of IL-2 levels and to a lesser extent of IL-4 in children with M. pneumoniae infection at the acute phase in our study, suggesting necessity of administration of therapeutic program for control of infectious inflammatory process in Mycoplasmal bronhoobstructive diseases.В исследование были включены 33 ребёнка, в возрасте 6 месяцев-7 лет, с диагнозом пневмония и обструктивный бронхит, для изучения влияния микоплазменной инфекции на уровень ИЛ-2, ИЛ-4. Было предусмотрено обследование пациентов при поступлении и повторное обследование через 1 месяц. Уровень ИЛ-2 в сыворотке крови детей с микоплазменной инфекцией составлял в среднем 31,80±2,26пг/мл, а в группе контроля – 39,27±3,17пг/мл. Значение содержания в крови ИЛ-4 в исследуемой группе было 46,92±2,93пг/мл и в группе контроля – 52,36±2,17пг/мл