Ask
Search
My library
ORKG

ORKG Ask

Our mission is to organize scholarly knowledge and make it accessible to humans and machines.

About

About ORKG Ask
Report issue
Statistics
Contact

Legal

Terms of use
Data protection (sheet)
Imprint
Accessibility
License

Technical

We
open source
System status
Changelog
Frontend: v1.41.0
Backend: v1.13.4

We use cookies to provide a better user experience.

Data Protection

cis-regulatory logic of Shh expression reveals common history of unpaired and paired fins

Martínez-Morales, Juan Ramón

Publication date

June 2021

Abstract

Trabajo presentado en el 5th European Zebrafish Principal Investigators Meeting, celebrado en Trento (Italia) del 20 al 23 de Marzo de 2018

Extracted data

Related items

Proposed gene network and timeline for the acquisition of anterior identity in the zebrafish otic vesicle.

Ryan D. Hartwell (6635045)
Samantha J. England (5037335)
Nicholas A. M. Monk (400260)
Nicholas J. van Hateren (6635048)
Sarah Baxendale (6635051)
Mar Marzo (6635054)
Katharine E. Lewis (5037323)
Tanya T. Whitfield (267479)

April 2019

(A) Proposed gene regulatory network. (B) Schematic timeline showing sequential onset of expression ...

Cooperation of sonic hedgehog enhancers in midline expression

Ertzer, Raymond
Müller, Ferenc
Hadzhiev, Yavor
Rathnam, Saradavey
Fischer, Nadine
Rastegar, Sepand
Strähle, Uwe

January 2007

AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...

Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish

Bessa, J.
Tena, J.J.
de la Calle-Mustienes, E.
Fernandez-Minan, A.
Naranjo, S.
Fernandez, A.
Montoliu, L.
Akalin, A.
Lenhard, B.
Casares, F.
Gomez-Skarmeta, J.L.

September 2009

The identification and characterization of the regulatory activity of genomic sequences is crucial f...

A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins

Letelier, Joaquin
Calle-Mustienes, Elisa de la
Pieretti, Joyce
Naranjo, Silvia
Maeso, Ignacio
Nakamura, Tetsuya
Pascual-Anaya, Juan
Shubin, Neil H.
Schneider, Igor
Martínez-Morales, Juan Ramón
Gómez-Skarmeta, José Luis

June 2021

Despite their evolutionary, developmental and functional importance, the origin of vertebrate paired...

Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes

Navratilova, Pavla
Fredman, David
Hawkins, Thomas A.
Turner, Katherine
Lenhard, Boris
Becker, Thomas S.

March 2009

AbstractPan-vertebrate developmental cis-regulatory elements are discernible as highly conserved non...

Dual-fluorescence transgenic analysis of a SHH enhancer SBE2 where a C>T change in a Six3 binding site has been identified in a patient with holoprosencephaly.

Shipra Bhatia (276505)
Christopher T. Gordon (384684)
Robert G. Foster (747801)
Lucie Melin (747802)
Véronique Abadie (240869)
Geneviève Baujat (747803)
Marie-Paule Vazquez (747804)
Jeanne Amiel (288851)
Stanislas Lyonnet (186137)
Veronica van Heyningen (57737)
Dirk A. Kleinjan (190236)

June 2015

<p><b>(A)</b> Regulatory landscape of SHH, depicting the location of the SBE2 enhancer. The sequence...

First-time cis-regulatory interactions between mammalian-specific TFs and the zebrafish genome: Understanding first time encounters in molecular evolution

López-Fernández, María José
Firbas, Panos
Maeso, Ignacio

January 2020

Resumen del trabajo presentado al VII Biennial Congress of the Spanish Society for Evolutionary Biol...

cis–regulation and mis–regulation – Insights into genomic regulatory mechanisms underlying the control of fgf8a in zebrafish Danio rerio

Komisarczuk, Anna Zofia

January 2008

Fibroblast growth factor 8 (Fgf8) is a potent vertebrate morphogen that plays decisive roles in mult...

Dual-fluorescence transgenic analysis of established CREs with disease-associated point mutations.

Shipra Bhatia (276505)
Christopher T. Gordon (384684)
Robert G. Foster (747801)
Lucie Melin (747802)
Véronique Abadie (240869)
Geneviève Baujat (747803)
Marie-Paule Vazquez (747804)
Jeanne Amiel (288851)
Stanislas Lyonnet (186137)
Veronica van Heyningen (57737)
Dirk A. Kleinjan (190236)

June 2015

<p><b>(A)</b> SHH-ZRS. (a) The regulatory landscape of SHH, depicting the location of ZRS enhancer. ...

Identification of Hox Regulatory Domains for Appendage Diversity and Fin-to-Limb Transition using Transgenic Zebrafish)

Zhang, Mickinney

April 2016

To reveal the molecular mechanisms of appendage diversity and the fin-to-limb transition, I am ident...

Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation

Silva, IAL
Cox, C. J.
Leite, Ricardo
Cancela, Leonor
Conceição, N.

October 2014

Transcriptional factor IIH (TFIIH) is involved in cell cycle regulation, nucleotide excision repair,...

Characterization of uptake and effects on gene expression of the shh-Inhibitor GANT 61 in zebrafish embryos

Hartmann, Franziska

January 2012

Die vorliegende Arbeit beschäftigt sich mit der Charakterisierung des shh-Inhibitors GANT-61, in den...

Functional Assessment of Disease-Associated Regulatory Variants <i>In Vivo</i> Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

Shipra Bhatia (276505)
Christopher T. Gordon (384684)
Robert G. Foster (747801)
Lucie Melin (747802)
Véronique Abadie (240869)
Geneviève Baujat (747803)
Marie-Paule Vazquez (747804)
Jeanne Amiel (288851)
Stanislas Lyonnet (186137)
Veronica van Heyningen (57737)
Dirk A. Kleinjan (190236)

June 2015

<div><p>Disruption of gene regulation by sequence variation in non-coding regions of the genome is n...

Sequential and cooperative action of Fgfs and Shh in the zebrafish retina

Vinothkumar, Saradavey
Rastegar, Sepand
Takamiya, Masanari
Ertzer, Raymond
Strähle, Uwe

February 2008

AbstractThe signaling molecule Sonic hedgehog (Shh) is required for differentiation of the vertebrat...

Upstream regulatory region of zebrafish lunatic fringe: Isolation and promoter analysis

Liu, Jing
Sun, Yong-Hua
Wang, Na
Wang, Ya-Ping
Zhu, Zuo-Yan
Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

July 2006

Lunatic fringe (Lfng), one modulator of Notch signaling, plays an essential part in demarcation of t...

Proposed gene network and timeline for the acquisition of anterior identity in the zebrafish otic vesicle.

Ryan D. Hartwell (6635045)
Samantha J. England (5037335)
Nicholas A. M. Monk (400260)
Nicholas J. van Hateren (6635048)
Sarah Baxendale (6635051)
Mar Marzo (6635054)
Katharine E. Lewis (5037323)
Tanya T. Whitfield (267479)

April 2019

(A) Proposed gene regulatory network. (B) Schematic timeline showing sequential onset of expression ...

Cooperation of sonic hedgehog enhancers in midline expression

Ertzer, Raymond
Müller, Ferenc
Hadzhiev, Yavor
Rathnam, Saradavey
Fischer, Nadine
Rastegar, Sepand
Strähle, Uwe

January 2007

AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...

Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish

Bessa, J.
Tena, J.J.
de la Calle-Mustienes, E.
Fernandez-Minan, A.
Naranjo, S.
Fernandez, A.
Montoliu, L.
Akalin, A.
Lenhard, B.
Casares, F.
Gomez-Skarmeta, J.L.

September 2009

The identification and characterization of the regulatory activity of genomic sequences is crucial f...

A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins

Letelier, Joaquin
Calle-Mustienes, Elisa de la
Pieretti, Joyce
Naranjo, Silvia
Maeso, Ignacio
Nakamura, Tetsuya
Pascual-Anaya, Juan
Shubin, Neil H.
Schneider, Igor
Martínez-Morales, Juan Ramón
Gómez-Skarmeta, José Luis

June 2021

Despite their evolutionary, developmental and functional importance, the origin of vertebrate paired...

Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes

Navratilova, Pavla
Fredman, David
Hawkins, Thomas A.
Turner, Katherine
Lenhard, Boris
Becker, Thomas S.

March 2009

AbstractPan-vertebrate developmental cis-regulatory elements are discernible as highly conserved non...

Dual-fluorescence transgenic analysis of a SHH enhancer SBE2 where a C>T change in a Six3 binding site has been identified in a patient with holoprosencephaly.

Shipra Bhatia (276505)
Christopher T. Gordon (384684)
Robert G. Foster (747801)
Lucie Melin (747802)
Véronique Abadie (240869)
Geneviève Baujat (747803)
Marie-Paule Vazquez (747804)
Jeanne Amiel (288851)
Stanislas Lyonnet (186137)
Veronica van Heyningen (57737)
Dirk A. Kleinjan (190236)

June 2015

<p><b>(A)</b> Regulatory landscape of SHH, depicting the location of the SBE2 enhancer. The sequence...

First-time cis-regulatory interactions between mammalian-specific TFs and the zebrafish genome: Understanding first time encounters in molecular evolution

López-Fernández, María José
Firbas, Panos
Maeso, Ignacio

January 2020

Resumen del trabajo presentado al VII Biennial Congress of the Spanish Society for Evolutionary Biol...

cis–regulation and mis–regulation – Insights into genomic regulatory mechanisms underlying the control of fgf8a in zebrafish Danio rerio

Komisarczuk, Anna Zofia

January 2008

Fibroblast growth factor 8 (Fgf8) is a potent vertebrate morphogen that plays decisive roles in mult...

Dual-fluorescence transgenic analysis of established CREs with disease-associated point mutations.

Shipra Bhatia (276505)
Christopher T. Gordon (384684)
Robert G. Foster (747801)
Lucie Melin (747802)
Véronique Abadie (240869)
Geneviève Baujat (747803)
Marie-Paule Vazquez (747804)
Jeanne Amiel (288851)
Stanislas Lyonnet (186137)
Veronica van Heyningen (57737)
Dirk A. Kleinjan (190236)

June 2015

<p><b>(A)</b> SHH-ZRS. (a) The regulatory landscape of SHH, depicting the location of ZRS enhancer. ...

Identification of Hox Regulatory Domains for Appendage Diversity and Fin-to-Limb Transition using Transgenic Zebrafish)

Zhang, Mickinney

April 2016

To reveal the molecular mechanisms of appendage diversity and the fin-to-limb transition, I am ident...

Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation

Silva, IAL
Cox, C. J.
Leite, Ricardo
Cancela, Leonor
Conceição, N.

October 2014

Transcriptional factor IIH (TFIIH) is involved in cell cycle regulation, nucleotide excision repair,...

Characterization of uptake and effects on gene expression of the shh-Inhibitor GANT 61 in zebrafish embryos

Hartmann, Franziska

January 2012

Die vorliegende Arbeit beschäftigt sich mit der Charakterisierung des shh-Inhibitors GANT-61, in den...

Functional Assessment of Disease-Associated Regulatory Variants <i>In Vivo</i> Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

Shipra Bhatia (276505)
Christopher T. Gordon (384684)
Robert G. Foster (747801)
Lucie Melin (747802)
Véronique Abadie (240869)
Geneviève Baujat (747803)
Marie-Paule Vazquez (747804)
Jeanne Amiel (288851)
Stanislas Lyonnet (186137)
Veronica van Heyningen (57737)
Dirk A. Kleinjan (190236)

June 2015

<div><p>Disruption of gene regulation by sequence variation in non-coding regions of the genome is n...

Sequential and cooperative action of Fgfs and Shh in the zebrafish retina

Vinothkumar, Saradavey
Rastegar, Sepand
Takamiya, Masanari
Ertzer, Raymond
Strähle, Uwe

February 2008

AbstractThe signaling molecule Sonic hedgehog (Shh) is required for differentiation of the vertebrat...

Upstream regulatory region of zebrafish lunatic fringe: Isolation and promoter analysis

Liu, Jing
Sun, Yong-Hua
Wang, Na
Wang, Ya-Ping
Zhu, Zuo-Yan
Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

July 2006

Lunatic fringe (Lfng), one modulator of Notch signaling, plays an essential part in demarcation of t...

Proposed gene network and timeline for the acquisition of anterior identity in the zebrafish otic vesicle.

Ryan D. Hartwell (6635045)
Samantha J. England (5037335)
Nicholas A. M. Monk (400260)
Nicholas J. van Hateren (6635048)
Sarah Baxendale (6635051)
Mar Marzo (6635054)
Katharine E. Lewis (5037323)
Tanya T. Whitfield (267479)

April 2019

(A) Proposed gene regulatory network. (B) Schematic timeline showing sequential onset of expression ...

Cooperation of sonic hedgehog enhancers in midline expression

Ertzer, Raymond
Müller, Ferenc
Hadzhiev, Yavor
Rathnam, Saradavey
Fischer, Nadine
Rastegar, Sepand
Strähle, Uwe

January 2007

AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...

Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish

Bessa, J.
Tena, J.J.
de la Calle-Mustienes, E.
Fernandez-Minan, A.
Naranjo, S.
Fernandez, A.
Montoliu, L.
Akalin, A.
Lenhard, B.
Casares, F.
Gomez-Skarmeta, J.L.

September 2009

The identification and characterization of the regulatory activity of genomic sequences is crucial f...