Exploring biomarkers associated with deteriorating vascular health using a targeted proteomics chip : The SABPA study
- Dieden, Anna
- Malan, Leone
- Mels, Catharina M C
- Lammertyn, Leandi
- Wentzel, Annemarie
- Nilsson, Peter M
- Gudmundsson, Petri
- Jujic, Amra
- Magnusson, Martin
DOIAbstract
ABSTRACT: In this observational study, by the use of a multiplex proteomic platform, we aimed to explore associations between 92 targeted proteins involved in cardiovascular disease and/or inflammation, and phenotypes of deteriorating vascular health, with regards to ethnicity.Proteomic profiling (92 proteins) was carried out in 362 participants from the Sympathetic activity and Ambulatory Blood Pressure in Africans (SABPA) study of black and white African school teachers (mean age 44.7 ± 9.9 years, 51.9% women, 44.5% Black Africans, 9.9% with known cardiovascular disease). Three proteins with <15% of samples below detectable limits were excluded from analyses. Associations between multiple proteins and prevalence of hypertension as well as...
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