Add to ORKGIn this work we report a microfluidic cell-culture platform with an integrated, actively-modulated actuator for the application of compressive forces on cancer cells. We show fabrication of the platform, mechanical characterization of the actuator and observed mechanotactic behavior of a monolayer of SKOV-3 ovarian cancer cells under static conditions. We further show compression and lysing of the cells, demonstrating suitability for mechanical stimulation with various pressures to study compressive forces in cancer microenvironments
Although high strain and strain-rate impacts to the human body have been the subject of substantial ...
Mechanical stimulation has been imposed on living cells using several approaches. Most early investi...
International audienceThis paper presents a novel technique for measuring the mechanical forces exer...
Evidence continues to emerge that cancer is not only a disease of genetic mutations, but also of al...
Evidence continues to emerge that cancer is not only a disease of genetic mutations, but also of alt...
Compressive solid stress correlates with changes in the mechanical properties of developing confined...
The physical forces to which living cells are most commonly exposed are fluid shear, pressure, and s...
Movement is essential to our quality of life, and regulates cell behavior via mechanical stimulation...
[[abstract]]In vitro devices offer more numerous methods than in vivo models to investigate how cell...
Cells in our body experience different types of stress including compression, tension, and shear. It...
Cells in our body experience different types of stress including compression, tension, and shear. It...
Mechanical stimuli interfere with cellular behaviors under many physiological conditions. To underst...
Cancer is a heterogeneous disease and the number of cancer deaths are rising. To know more about it ...
International audienceCells need to act upon the elastic extracellular matrix and against steric con...
Determining how biological cells respond to external factors in the environment can aid in understan...
Although high strain and strain-rate impacts to the human body have been the subject of substantial ...
Mechanical stimulation has been imposed on living cells using several approaches. Most early investi...
International audienceThis paper presents a novel technique for measuring the mechanical forces exer...
Evidence continues to emerge that cancer is not only a disease of genetic mutations, but also of al...
Evidence continues to emerge that cancer is not only a disease of genetic mutations, but also of alt...
Compressive solid stress correlates with changes in the mechanical properties of developing confined...
The physical forces to which living cells are most commonly exposed are fluid shear, pressure, and s...
Movement is essential to our quality of life, and regulates cell behavior via mechanical stimulation...
[[abstract]]In vitro devices offer more numerous methods than in vivo models to investigate how cell...
Cells in our body experience different types of stress including compression, tension, and shear. It...
Cells in our body experience different types of stress including compression, tension, and shear. It...
Mechanical stimuli interfere with cellular behaviors under many physiological conditions. To underst...
Cancer is a heterogeneous disease and the number of cancer deaths are rising. To know more about it ...
International audienceCells need to act upon the elastic extracellular matrix and against steric con...
Determining how biological cells respond to external factors in the environment can aid in understan...
Although high strain and strain-rate impacts to the human body have been the subject of substantial ...
Mechanical stimulation has been imposed on living cells using several approaches. Most early investi...
International audienceThis paper presents a novel technique for measuring the mechanical forces exer...