Studies on the cimetidine resistant duodenal ulcer

  • Gledhill, T.
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Publication date
January 1982
Publisher
The University of Edinburgh
Language
English

Abstract

This thesis investigates why some patients with duodenal ulcer do not respond to blockade and how these patients should be treated. Part 1 examines the effect of cimetidi.'ne lg/day, cimetidine 2g/day and vagotomy on nocturnal gastric secretion in nonresponders. Cimetidine in either dose had no significant effect on volume of gastric secretion but nocturnal intragastric acidity did show a significant decrease. Vagotomy significantly decreased both volume and acidity of secretion. These findings suggest that nonresponse to cimetidine may be due to increased vagal drive. Part 2 investigates vagal function further by measuring nocturnal pepsin secretion in patients receiving cimetidine and ranitidine. Both H2~receptor antagonists in...

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