The highly unstructured interferon regulated transcription factor IRF-1 is a tumour suppressor protein that plays vital roles in the antiviral and DNA damage response pathways. To identify interacting factors that regulate IRF-1 function and expand on the available limited information on its interactome, an in vitro screen was developed using peptide-aptamer affinity chromatography coupled with mass spectrometry. Discrete identified which bind to a number of potential transcriptional regulators including NPM1, YB-1 and TRIM28. The screen also proved useful in identifying binding proteins to the C-terminal Mf1 domain, which is vital for IRF-1-mediated growth suppression and Cdk2 repression, and additionally regulates IRF-1 stability. Thus, a...
The tumor suppressor IRF-1 has been gaining interest as a mediator of anticancer therapies and its r...
Interferon regulatory factor 1 (IRF-1) is a tumour suppressor protein and transcription factor. It...
Interferon regulatory factor-1 (IRF-1) is a transcription factor and tumour suppressor, involved in...
Our understanding of the post-translational processes involved in regulating the interferon regulato...
Characteristically for a regulatory protein, the IRF-1 tumor suppressor turns over rapidly with a ha...
The interferon-regulated transcription factor and tumor suppressor protein IRF-1 is predicted to be ...
Understanding the determinants for site-specific ubiquitination by E3 ligase components of the ubiqu...
IRF1 is a transcription factor involved in interferon signaling and has been shown to harbor tumor s...
Interferon regulatory factor 1 (IRF-1) is a tumour suppressor protein and transcription factor. It h...
Interferon Regulatory Factor 1 (IRF1) was the first characterised member of the Interferon Regulator...
IRF1 is a transcription factor that regulates key processes in the immune system and in tumour suppr...
Interferon Regulatory Factor -1 (IRF-1) is a transcription factor that acts as a tumour suppressor ...
IRF-1 (Interferon Regulatory Factor 1) is a transcription factor first identified as a regulator of ...
IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcriptio...
The production of IFN- I (IFN-a/b) is one of the earliest and most important host-protective respons...
The tumor suppressor IRF-1 has been gaining interest as a mediator of anticancer therapies and its r...
Interferon regulatory factor 1 (IRF-1) is a tumour suppressor protein and transcription factor. It...
Interferon regulatory factor-1 (IRF-1) is a transcription factor and tumour suppressor, involved in...
Our understanding of the post-translational processes involved in regulating the interferon regulato...
Characteristically for a regulatory protein, the IRF-1 tumor suppressor turns over rapidly with a ha...
The interferon-regulated transcription factor and tumor suppressor protein IRF-1 is predicted to be ...
Understanding the determinants for site-specific ubiquitination by E3 ligase components of the ubiqu...
IRF1 is a transcription factor involved in interferon signaling and has been shown to harbor tumor s...
Interferon regulatory factor 1 (IRF-1) is a tumour suppressor protein and transcription factor. It h...
Interferon Regulatory Factor 1 (IRF1) was the first characterised member of the Interferon Regulator...
IRF1 is a transcription factor that regulates key processes in the immune system and in tumour suppr...
Interferon Regulatory Factor -1 (IRF-1) is a transcription factor that acts as a tumour suppressor ...
IRF-1 (Interferon Regulatory Factor 1) is a transcription factor first identified as a regulator of ...
IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcriptio...
The production of IFN- I (IFN-a/b) is one of the earliest and most important host-protective respons...
The tumor suppressor IRF-1 has been gaining interest as a mediator of anticancer therapies and its r...
Interferon regulatory factor 1 (IRF-1) is a tumour suppressor protein and transcription factor. It...
Interferon regulatory factor-1 (IRF-1) is a transcription factor and tumour suppressor, involved in...