Sulphanilamides in gonorrhoea

Sulphanilamide, sulphapyridine and sulphathiazole are exceedingly potent drugs in the treatment of gonorrhoea, and there is not much to choose between them in the matter of cure. Toxic effects were frequent but were never severe. They were much more marked with sulphapyridine, especially in the female, but we seem to have found the solution to this in sulphathiazole. All cases need observation and strict instructions how to take the drug in order to secure the maximum benefit. It is not enough to give a box of tablets, promise cure, and neglect tests for cure. Relapses occurred in the majority of cases after inadequate doses given by the patients' private practitioners, and no good results can be obtained by using the suiphanilamides again in adequate doses until the patient loses his drug resistance which takes about fourteen days. Sulphapyridine should in an uncomplicated case dry up discharge in twenty-four hours. If it fails to do so, suspect complication. The Gonococcal Complement Fixation test in the male is of importance as a test in doubtful clinical cases without a positive smear, and in the female as a test for cure. Early cases under treatment with sulphapyridine (M & B 693) however, never become positive